Scleroderma

Scleroderma is an autoimmune disorder whose hallmark is increased collagen deposition and hardening of the skin.

While research continues to evolve our understanding of this disease, the main feature is abnormal function of fibroblast cells leading to the increased collagen deposition.

The increased deposition can lead to changes in the skin, kidneys, gastrointestinal tract, and other areas.  This family of diseases often shares clinical features with inflammatory muscle diseases, mixed connective tissue disease (MCTD), rheumatoid arthritis, and Sjogren’s syndrome.  Many different organ systems can become involved including the pulmonary and cardiac systems.

The classically described forms are diffuse cutaneous systemic sclerosis (common referred to as “scleroderma”), and limited cutaneous systemic sclerosis (commonly referred to as CREST syndrome- Calcinosis, Raynaud’s phenomenon, Esophageal dysmotility, Sclerodactyly, and Telangiectasias).  Diffuse cutaneous systemic sclerosis tends to involve more proximal skin changes, and can be associated with interstitial lung disease.  Limited cutaneous systemic sclerosis generally shows more distal skin changes, can involve the problems listed in the letters “CREST”, and can be associated with primary pulmonary hypertension.

Scleroderma related disorders can be quite severe.  However, with appropriate recognition and diagnosis, many of the problems can be anticipated and/or managed.  There are newer approaches to treat the most severe forms of disease including interstitial lung disease and primary pulmonary hypertension.  These problems are often co-managed with pulmonary physicians and cardiologists.

Apr 20, 2018

Reclaim: Five Foods to Help Manage Gout

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Gout is a form of arthritis that is caused by chronically elevated levels of uric acid in the diet.  The uric acid eventually forms crystals, which can be deposited in different joints. As those who suffer from gout know, severe attacks can be debilitating. Fortunately, this condition is very treatable with a doctor’s care and a […]

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Apr 9, 2018

Spring Cleaning Tips to Save Your Joints

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There is nothing that quite compares to a sparkling clean home, and there is no better time to get it sparkling than the spring. However, for those who suffer from joint pain, this can be a difficult task. Here are a few tips to make spring cleaning a little bit easier. Pace yourself. Do not […]

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Mar 16, 2018

The Potential Link between Seasonal Allergies and Rheumatoid Arthritis

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Spring is in the air! Unfortunately, it’s full of allergens too. For those who suffer from rheumatoid arthritis (RA), this can be a problem. Experts are beginning to notice a potential connection between seasonal allergies and rheumatoid arthritis. As we are in the thick of pollen season here in Southeastern North Carolina, this theory is […]

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